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7-chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one
Lorazepam is a benzodiazepine that primarily acts by enhancing GABA-A receptor activity. It is medically used for the treatment of anxiety disorders, sleep disturbances, and seizures. The substance possesses sedative, anxiolytic, and muscle-relaxant properties. Due to its potential for dependence, Lorazepam should only be used under medical supervision.
Receptor Targets
Mechanism of Action
Designations
IUPAC: Lorazepam
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der GABA-A-Rezeptor ist ein ligandengesteuerter Chloridkanal und der wichtigste inhibitorische Rezeptor im zentralen Nervensystem. Er besitzt multiple allosterische Bindungsstellen für verschiedene Substanzklassen.
Effects & Pharmacology is partially translated. Some content may appear in German.
Lorazepam ist ein hochpotentes Benzodiazepin und positiv-allosterischer Modulator von GABAA-Rezeptoren. Bindet an die Benzodiazepinbindungsstelle (zwischen α- und γ-Untereinheiten) und erhöht die Affinität von GABA für den Rezeptor, was den Cl⁻-Einstrom verstärkt (Hyperpolarisation). Im Gegensatz zu Diazepam: Konjugation durch direkte Glucuronidierung in der Leber (kein CYP450-Abbau) — dadurch weniger pharmakokinetische Interaktionen. Halbwertszeit 10-20h (intermediär). Kein aktiver Hauptmetabolit.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 6-8 hours
Peak
2-4 hours
Onset
30-60 minutes
Total duration
6-8 hours
After effects
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Evidence
strong
Neurotoxicity
possible
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Alcohol
Opioids
Antidepressants
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.