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1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
Meclizine is an antihistamine of the piperazine class, primarily used as an antiemetic for the treatment of nausea and dizziness. It acts by blocking H1 receptors and possesses anticholinergic properties that contribute to the alleviation of motion sickness symptoms. Due to its sedative effect, it should be used with caution, especially in combination with other central depressants.
Class
Piperazine
Pharmacological context
Mechanism
Meclizine wirkt durch die Blockade von H1-Histaminrezeptoren und hat...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Designations
IUPAC: 1-[(4-chlorophenyl)-phenyl-methyl]-4-(3-methylbenzyl)piperazine
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Reported range 25 mg
Total duration 6–8 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 12.5 mg |
| Reported | 25 mg |
| Strong | 50 mg |
Oral
Onset
1 hour
Peak
2–3 hours
Total duration
6–8 hours
After effects
1–2 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen sind Schläfrigkeit, Mundtrockenheit und Schwindel.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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