Laden…
2-(methylamino)-1-(4-methylphenyl)propan-1-one
Mephedrone is a synthetic stimulant from the class of cathinones, primarily acting through the inhibition of the reuptake of dopamine, norepinephrine, and serotonin. It produces stimulating and euphoric effects but can also cause side effects such as palpitations, anxiety, and neurotoxic effects. The substance is often consumed as a designer drug and carries a moderate risk for acute and chronic health damage.
Class
Cathinone
Pharmacological context
Mechanism
Mephedrone primarily acts as an inhibitor of the reuptake of dopamine,...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: 2-(methylamino)-1-(p-tolyl)propan-1-one
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Mephedrone primarily acts as an inhibitor of the reuptake of dopamine, serotonin, and norepinephrine. This leads to an increased availability of these neurotransmitters in the synaptic cleft and enhances their effect in the central nervous system.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 100–200 mg
Total duration 3–6 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 50–100 mg |
| Reported | 100–200 mg |
| Strong | 200–300 mg |
Nasal
| Tier | Dosage |
|---|---|
| Light | 30–60 mg |
| Reported | 60–120 mg |
| Strong | 120–180 mg |
Onset
15–30 minutes
Peak
1–2 hours
Total duration
3–6 hours
After effects
1–3 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Neurotoxicity
possible
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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