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cis-(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide
Milnacipran is a selective serotonin-norepinephrine reuptake inhibitor primarily used for the treatment of depression and fibromyalgia. It works by inhibiting the reuptake of serotonin and norepinephrine in the central nervous system, which increases the availability of neurotransmitters. The substance has a moderate adverse effects profile and is often used in patients who do not respond adequately to other antidepressants.
Class
Serotonin-Noradrenalin-Wiederaufnahmehemmer
Pharmacological context
Mechanism
Milnacipran wirkt durch die Hemmung der Wiederaufnahme von Serotonin...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: cis-(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropanecarboxamide
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der Serotonintransporter (SERT/5-HTT) ist ein Natrium-abhängiger Monoamintransporter, der Serotonin aus dem synaptischen Spalt zurück in die präsynaptische Zelle transportiert. Er ist das primäre Ziel von SSRI und MDMA.
Der Noradrenalintransporter (NET) ist ein Monoamintransporter, der Noradrenalin aus dem synaptischen Spalt zurücktransportiert. Er wird von verschiedenen Stimulants und Antidepressiva beeinflusst.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Milnacipran wirkt durch die Hemmung der Wiederaufnahme von Serotonin und Noradrenalin im zentralen Nervensystem, was zu einer erhöhten Verfügbarkeit dieser Neurotransmitter führt.
Reported range 100–200 mg
Oral
| Tier | Dosage |
|---|---|
| Light | 25–50 mg |
| Reported | 100–200 mg |
| Strong | 300 mg |
Oral
Onset
1–2 weeks
Peak
4–6 weeks
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Übelkeit, Schwindel und Schlaflosigkeit.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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