Laden…
Synapedia is an independent knowledge project about psychoactive substances and harm reduction. If the platform helps you learn something new, you can support its development.
Every bit helps keep the project alive.
5-(aminomethyl)-1,2-oxazol-3-one
Muscimol is a substance from the class of isoxazoles. Further information will follow after enrichment.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Muscimol acts through the following pharmacological mechanisms:
Designations
IUPAC: 5-(aminomethyl)-4-isoxazolin-3-one
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der GABA-A-Rezeptor ist ein ligandengesteuerter Chloridkanal und der wichtigste inhibitorische Rezeptor im zentralen Nervensystem. Er besitzt multiple allosterische Bindungsstellen für verschiedene Substanzklassen.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class. Limited data — interpret profile with caution.
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration 4-8 hours
Peak
1-2 hours
Onset
30-60 minutes
Total duration
4-8 hours
After effects
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Summary
Mögliche Nebenwirkungen umfassen Übelkeit, Schwindel und Verwirrtheit.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some combinations can be dangerous. Research before combining substances.
Synergistische GABA-A-Aktivierung und ZNS-Depression
Muscimol (Wirkstoff von Amanita muscaria/Fliegenpilz) ist ein direkter GABA-A-Agonist — im Gegensatz zu Benzodiazepinen (allosterische Modulatoren) bindet Muscimol direkt an die GABA-Bindungsstelle. Ethanol potenziert GABA-A über eine eigene allosterische Bindungsstelle und blockiert zusätzlich NMDA-Rezeptoren. Die Kombination erzeugt synergistische GABAerge Depression. Die Dosierung von Muscimol aus natürlichen Pilzquellen ist extrem variabel (pilzteilabhängig, saisonabhängig, standortabhängig) — eine sichere Dosisfindung in Kombination mit Alkohol ist nicht möglich.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.