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Nicotine is an alkaloid of the tobacco plant that acts as an agonist at nicotinic acetylcholine receptors. It has a high potential for dependence and influences dopaminergic neurotransmission.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Nikotin acts through the following pharmacological mechanisms:
Receptor Profile
Nikotinische Acetylcholinrezeptoren (nAChR) sind ligandengesteuerte Ionenkanäle, die durch Acetylcholin und Nikotin aktiviert werden. Sie spielen eine Rolle bei Kognition, Aufmerksamkeit und neuromuskulärer Übertragung.
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Risks & Harm Reduction — Translation in progress
This section is being translated. Content is available in German.
View in German →The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Geringes Risiko: Additive milde Effekte
Nikotin (nACh-Rezeptor-Agonist) und THC (CB1-Agonist) wirken über pharmakologisch unabhängige Rezeptorsysteme. Beide erhöhen die Herzfrequenz: Nikotin über direkte sympathische Aktivierung und Katecholaminfreisetzung, THC über Reduktion des parasympathischen Tonus. Langfristig ist der kombinierte Konsum über Tabak/Cannabis-Mischkonsum (Joint) die epidemiologisch relevanteste Exposition. Kurzfristige Wechselwirkungen sind mild — die Hauptrisiken sind chronisch (Lunge, Kreislauf), nicht akut.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.