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1-[4-(4-fluorophenyl)-4-oxobutyl]-4-piperidin-1-ylpiperidine-4-carboxamide
Pipamperone is a typical antipsychotic from the group of butyrophenones, primarily acting as a dopamine D2 and serotonin 5-HT2A antagonist. It is mainly used for the treatment of schizophrenia and other psychotic disorders and possesses sedative properties. The substance also affects alpha-1 adrenergic receptors, which can lead to side effects such as orthostasis. Due to its pharmacological profile, the risk for extrapyramidal side effects is moderate.
Class
Butyrophenone
Pharmacological context
Mechanism
5-HT2A antagonist, D2 antagonist
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Pipamperone acts through the following pharmacological mechanisms:
Designations
IUPAC: 1-[4-(4-fluorophenyl)-4-keto-butyl]-4-piperidino-isonipecotamide
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der 5-HT2A-Rezeptor ist ein Serotonin-Rezeptor der Klasse Gq-gekoppelter GPCRs. Er ist der primäre molekulare Angriffspunkt klassischer Psychedelika und spielt eine Rolle bei Kognition und Wahrnehmung.
Der D2-Rezeptor ist ein Gi-gekoppelter Dopaminrezeptor mit hoher Dichte im Striatum. Er ist ein wichtiges Ziel für Antipsychotika und moduliert motorische Funktionen sowie Belohnungsverarbeitung.
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Reported range 2–10 mg
Total duration 24 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 1–2 mg |
| Reported | 2–10 mg |
| Strong | 10–20 mg |
Oral
Onset
1–3 hours
Peak
4–6 hours
Total duration
24 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Sedierung, Gewichtszunahme und extrapyramidale Symptome.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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