Synapedia is an independent knowledge project about psychoactive substances and harm reduction. If the platform helps you learn something new, you can support its development.
Every bit helps keep the project alive.
Evidence-based risk assessment and known adverse effects
Risk Classification: Moderate Risk
2C-E carries a moderate risk profile. Acute and chronic risks depend significantly on dose, frequency, route of administration, and individual predispositions.
Neurotoxicity
none_known
The following substances carry an elevated risk of adverse interactions with 2C-E. This list is not exhaustive.
For a full interaction overview, see the Interactions page.
general
2C-E gilt als die intensivste und körperlich anstrengendste der 2C-x-Verbindungen — mit Respekt dosieren
dosing
Oral: 8–12 mg für Erstanwender. Dosis-Response sehr steil — kleine Änderungen haben große Wirkung
dosing
Wirkungseintritt 60–90 Minuten oral — nicht früh nachdosieren
health
Körperliche Belastung (Zittern, Kälte, Übelkeit) tritt häufiger auf als bei LSD — physisch belastbar sein
combinations
Kein Lithium, keine MAO-Hemmer
safety
Bekannte Todesfälle bei unbeaufsichtigtem Konsum — Tripsitter obligatorisch bei Dosen über 15 mg
Disclaimer: This information is provided for educational purposes only and does not constitute medical advice. If you have concerns about substance use, please consult a qualified healthcare professional or contact a local drug support service.