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5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid and a direct precursor of serotonin. It is commonly used as a dietary supplement to support serotonin production in the brain, which can positively affect mood and sleep. The substance works by increasing the availability of serotonin, influencing various serotonin receptors, and is well tolerated. Risks mainly exist when taken concurrently with serotonergic medications.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Designations
IUPAC: 5-HTP (5-Hydroxytryptophan)
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Effects & Pharmacology is partially translated. Some content may appear in German.
5-HTP acts as a precursor to serotonin by increasing serotonin production in the brain. This leads to an increase in the availability of serotonin at the synapses, resulting in various physiological and psychological effects.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 4-6 hours
Peak
1-2 hours
Onset
30-60 minutes
Total duration
4-6 hours
After effects
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Summary
Mögliche Nebenwirkungen sind Übelkeit, Durchfall und Schläfrigkeit. Wechselwirkungen mit anderen Medikamenten sind möglich.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
MAO inhibitors
Antidepressants
Sleep medications
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.