Cannabis
smokeding awake for about 30 hours.
Fin
Cannabis
Laden…
(1E,4E,8E)-2,6,6,9-tetramethylcycloundeca-1,4,8-triene
Cannabis is a psychoactive plant that primarily acts through its cannabinoids, which bind to CB1 and CB2 receptors in the central and peripheral nervous system. The substance affects various neurotransmitter systems and can induce relaxing, analgesic, and appetite-stimulating effects. Consumption carries moderate risks, particularly regarding mental health and potential for dependence.
Class
Cannabinoide
Pharmacological context
Mechanism
Cannabis ist eine Ganzpflanze mit komplexem pharmakologischem Profil,...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: Cannabis
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Cannabis ist eine Ganzpflanze mit komplexem pharmakologischem Profil, das deutlich über den Effekt von isoliertem THC hinausgeht. Der primäre psychoaktive Wirkstoff Δ9-THC wirkt als partieller Agonist an CB1-Cannabinoidrezeptoren im ZNS (besonders Basalganglien, Hippocampus, Kleinhirn, präfrontaler Kortex) und CB2-Rezeptoren im Immunsystem. Cannabidiol (CBD) hat keine direkte CB1-Agonistwirkung, moduliert jedoch allosterisch CB1 (negative Modulation — reduziert THC-induzierte Angst und Tachykardie), antagonisiert GPR55, hemmt den endocannabinoiden Abbau (FAAH-Hemmung) und wirkt als 5-HT1A-Agonist. THC/CBD-Interaktion ist klinisch relevant: höhere CBD-Anteile im Produkt dämpfen anxiogene und psychotomimetische THC-effects. Terpene (Myrcen, Limonen, Beta-Caryophyllen, Linalool) und Minorkannabnoide (CBN, CBG, THCV) tragen zum "Entourage-Effekt" bei — synergistische pharmakologische Interaktionen, die Reinsubstanz-THC pharmakokinetisch und -dynamisch von Ganzpflanzenprodukten unterscheiden. Geraucht beginnt die Wirkung innerhalb von Minuten durch rasche pulmonale Absorption; oral (Edibles) verzögert sich der Onset auf 30–120 Minuten wegen hepatischer First-Pass-Metabolisierung, bei der THC zu 11-Hydroxy-THC (stärker, länger wirkend) umgewandelt wird.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 10–20 mg
Total duration 2–4 hours (smoked/vaporized), 4–8 hours (oral)
Oral
| Tier | Dosage |
|---|---|
| Light | 2.5–5 mg |
| Reported | 10–20 mg |
| Strong | 30–50 mg |
Geraucht
| Tier | Dosage |
|---|---|
| Light | 1–3 mg |
| Reported | 5–10 mg |
| Strong | 15–30 mg |
Vaporisiert
| Tier | Dosage |
|---|---|
| Light | 1–3 mg |
| Reported | 5–10 mg |
| Strong | 15–30 mg |
Onset
5–10 minutes (smoked/vaporized), 30–90 minutes (oral)
Peak
30–60 minutes (smoked/vaporized), 2–3 hours (oral)
Total duration
2–4 hours (smoked/vaporized), 4–8 hours (oral)
After effects
1–3 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Evidence
Umfangreiche klinische und epidemiologische Literatur. Größte Evidenzbasis unter allen Substanzen auf dieser Plattform. Besonders Adoleszenten-Neurotoxizität gut belegt.
Neurotoxicity
possible
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Community summaries. Not consumption guidance.
Cannabis
Experiences + discussions about Cannabis
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Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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These entries are submitted by users and are not verified. They may contain subjective experiences, observations, source leads, or corrections. They do not replace scientific data and are not consumption advice.
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