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Kratom (Mitragyna speciosa) is a plant substance with opioid-like effects, primarily mediated by alkaloids such as mitragynine. It acts mainly as a partial agonist at μ-opioid receptors and additionally influences other receptor systems. Kratom is traditionally used for pain relief and to enhance energy and mood. The substance carries a moderate risk of dependence and side effects, especially with prolonged use.
Class
Opioide
Pharmacological context
Mechanism
Kratom enthält zwei pharmakologisch relevante Alkaloide: Mitragynin und...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: Kratom (Mitragyna speciosa)
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class. Limited data — interpret profile with caution.
Synapedia Evidence
Frequently checked combinations
Effects & Pharmacology is partially translated. Some details are still being expanded.
Kratom enthält zwei pharmakologisch relevante Alkaloide: Mitragynin und 7-Hydroxymitragynin (7-HMG). Mitragynin wirkt bei niedrigen Dosen primär als α2-adrenerger Agonist und moduliert Serotonin-/Dopaminwiederaufnahme (stimulierende Effekte). Bei höheren Dosen wird 7-HMG zum dominanten Wirkstoff: Es ist ein partieller Agonist an μ-Opioid-Rezeptoren mit ca. 13-facher Potenz gegenüber Morphin (tierexperimentell). 7-HMG aktiviert zusätzlich δ- und κ-Opioid-Rezeptoren. Mitragynin wird hepatisch durch CYP3A4/2D6 zu 7-HMG metabolisiert, was die duale Wirkpharmakologie erklärt.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 2–5 g
Total duration 4–6 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 1–2 g |
| Reported | 2–5 g |
| Strong | 5–10 g |
Oral
Onset
30–60 minutes
Peak
1–2 hours
Total duration
4–6 hours
After effects
2–4 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Safer Use
Depressant-risk context
This substance belongs to a context where combinations with opioids, benzodiazepines, alcohol, GHB/GBL, or other sedating substances can increase sedation, blackout, aspiration, and breathing-risk patterns. Risk Check can review warning patterns; it is not medical advice and it cannot clear a combination as safe.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Experiences + discussions about Kratom (Mitragyna speciosa)
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Based on substance class, receptors, mechanisms, and effect profile.
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