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N-phenyl-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide
Fentanyl is a highly potent synthetic opioid that is primarily used as an analgesic and anesthetic. It acts as an agonist at the μ-opioid receptor and has a high potential for addiction and dependence. Due to its strong effects, there is a significant risk of respiratory depression and overdose. Fentanyl is used under medical supervision but is also associated with a high risk of abuse and death.
Receptor Targets
Mechanism of Action
Designations
IUPAC: N-(1-phenethyl-4-piperidyl)-N-phenyl-propionamide
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class. Limited data — interpret profile with caution.
Fentanyl acts as an agonist at μ-opioid receptors in the central nervous system, leading to significant pain relief. It also affects the reward system, contributing to a high potential for dependence.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 1-3 hours (intravenous), 72 hours (transdermal)
Peak
30-60 minutes (intravenous), 24-36 hours (transdermal)
Onset
1-5 minutes (intravenous), 12-24 hours (transdermal)
Total duration
1-3 hours (intravenous), 72 hours (transdermal)
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Evidence
strong
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some combinations can be dangerous. Research before combining substances.
Lebensbedrohlich: Atemdepression durch doppelte ZNS-Hemmung
Fentanyl ist ein hochpotenter μ-Opioid-Agonist, der den Atemantrieb im Hirnstamm unterdrückt. Benzodiazepine potenzieren die GABAerge Hemmung, was den Atemantrieb zusätzlich reduziert. Diese Kombination ist die weltweit häufigste Ursache für substanzbezogene Todesfälle. Bereits geringe Mengen beider Substanzen können zu tödlicher Atemdepression führen, insbesondere bei opioidnaiven Personen.
Lebensbedrohlich: Extreme Atemdepression durch hochpotentes Opioid und Alkohol
Fentanyl ist ein synthetisches Opioid mit extrem hoher Potenz am μ-Opioidrezeptor. Ethanol wirkt als ZNS-Depressivum über GABA-A-Rezeptoren und NMDA-Antagonismus. Die Kombination potenziert die atemdepressive Wirkung erheblich. Die enge therapeutische Breite von Fentanyl macht diese Interaktion besonders gefährlich — bereits geringe Schwankungen in der ZNS-Dämpfung können lebensbedrohlich sein.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.