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2-(3,4,5-trimethoxyphenyl)ethylamine
Mescaline is a naturally occurring psychedelic phenethylamine, primarily found in certain species of cacti. It acts mainly as an agonist at the 5-HT2A receptor and induces altered perceptions and states of consciousness. The substance is traditionally used in ritual contexts and has a moderate risk profile, particularly regarding psychological stress.
Class
Not clearly classified yet
Pharmacological context
Mechanism
Mescaline primarily acts as an agonist at the 5-HT2A receptor, leading...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: 2-(3,4,5-trimethoxyphenyl)ethylamine
Synapedia Evidence
Mescaline primarily acts as an agonist at the 5-HT2A receptor, leading to changes in perception, mood, and cognition. It also affects other serotonergic systems that contribute to the psychedelic experience.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 300–500 mg
Total duration 8–12 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 200–300 mg |
| Reported | 300–500 mg |
| Strong | 500–800 mg |
Oral
Onset
30–90 minutes
Peak
2–4 hours
Total duration
8–12 hours
After effects
2–6 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Overdose Risk
Keine bekannte letale Dosis durch pharmakologische Toxizität beim Menschen. Akute Risiken sind psychiatrisch (intensive Dysphorie, Panik) und somatisch (Hyperthermie, Hypertension). Supportive Behandlung: beruhigende Umgebung, Benzodiazepine bei starker Agitation.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Community summaries. Not consumption guidance.
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Experiences + discussions about Mescalin
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Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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