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Modafinil is a wakefulness-promoting stimulant primarily used for the treatment of narcolepsy and other sleep disorders. It primarily acts by inhibiting the reuptake of dopamine and norepinephrine as well as by modulating the orexin system. The substance has a lower potential for abuse than classic stimulants but can cause side effects with improper use. Modafinil is also used off-label to enhance cognitive performance.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Designations
IUPAC: 2-benzhydrylsulfinylacetamide
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration 10-12 hours
Peak
2-4 hours
Onset
30-60 minutes
Total duration
10-12 hours
After effects
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Maskierte Alkoholintoxikation und hepatische Interaktion
Modafinil fördert Wachheit über DAT-Inhibition, Histamin- und Orexin-Aktivierung. Die stimulierende Wirkung kann die subjektive Wahrnehmung der Alkoholintoxikation reduzieren, was zu weiterem Alkoholkonsum führt. Modafinil induziert CYP3A4, was zu pharmakokinetischen Interaktionen führen kann.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.