Laden…
(2R)-N-methyl-1-phenyl-N-prop-2-ynylpropan-2-amine
Selegiline is a selective and irreversible MAO-B inhibitor that is primarily used for the treatment of Parkinson's disease. By inhibiting MAO-B, it increases the availability of dopamine in the brain and may possess neuroprotective effects. Side effects and interactions with other substances require careful application. It is also being investigated in research for its antidepressant and neuroprotective properties.
Class
MAO-Hemmer
Pharmacological context
Mechanism
Selegiline ist ein selektiver Hemmer des Monoaminoxidase B (MAO-B), der...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Designations
IUPAC: methyl-[(1R)-1-methyl-2-phenyl-ethyl]-propargyl-amine
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Monoaminoxidase A (MAO-A) ist ein mitochondriales Enzym, das Serotonin, Noradrenalin und Dopamin oxidativ desaminiert. Hemmung führt zu erhöhten Monoamin-Spiegeln und ist die Grundlage der MAO-Hemmer-Therapie bei Depression.
Monoaminoxidase B (MAO-B) ist ein mitochondriales Enzym, das bevorzugt Phenylethylamin, Benzylamin und Dopamin abbaut. Selektive MAO-B-Hemmer werden bei Morbus Parkinson eingesetzt.
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Reported range 10–20 mg
Total duration 24 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 5 mg |
| Reported | 10–20 mg |
| Strong | 30 mg |
Oral
Onset
1–2 hours
Peak
4–6 hours
Total duration
24 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Schlaflosigkeit, Schwindel und gastrointestinale Beschwerden.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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