Laden…
St. John's Wort (Hypericum perforatum) is a herbal preparation primarily used for the treatment of mild to moderate depression. It mainly acts by inhibiting the reuptake of neurotransmitters such as serotonin, norepinephrine, and dopamine. Additionally, it modulates GABA and glutamate receptors, contributing to a mood-enhancing effect. Caution is advised due to interactions with other medications.
Class
Pflanzliche Arzneimittel
Pharmacological context
Mechanism
Johanniskraut wirkt durch die Hemmung der Wiederaufnahme von Serotonin,...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Designations
IUPAC: St. John's Wort (Hypericum)
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Reported range 600 mg
Oral
| Tier | Dosage |
|---|---|
| Light | 300 mg |
| Reported | 600 mg |
| Strong | 1200 mg |
Oral
Onset
1–2 weeks
Peak
4–6 weeks
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Kann Wechselwirkungen mit anderen Medikamenten haben und sollte mit Vorsicht verwendet werden.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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