Primary risk
Primary risk: cardiovascular strain
Combinations significantly increase cardiac risk.
SuspectedLaden…
3-CMC (3-chloromethcathinone, also called clophedrone) is a synthetic cathinone research chemical with stimulant, monoaminergic effects. EUDA/EMCDDA and WHO assessments identify 3-CMC as a new psychoactive substance associated with health risks, while human pharmacology is less well characterised than for established stimulants. The page therefore treats timelines and dose claims cautiously. Key concerns include tachycardia, hypertension, hyperthermia, anxiety or panic, seizures, sleep deprivation, compulsive redosing, and hazardous combinations with MAOIs, serotonergic medicines, MDMA, amphetamines, cocaine, tramadol or lithium.
Class
Stimulants
Pharmacological context
Mechanism
Monoamin-Transporter-bezogene Stimulanzwirkung;...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
High Risk
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Newly emerging RC with stimulant-like profile — cardiovascular risk, no validated human data.
Evidence confidence
Critical risk signals
Combinations significantly increase cardiac risk.
SuspectedFurther risks (class-based)
Combinations significantly increase cardiac risk.
Synapedia is actively monitoring this substance. Data is updated as new signals emerge.
Scientific interpretation
Why is this substance flagged?
This substance is flagged because structural-chemical features indicate a stimulant-like profile. Cardiovascular strain is class-documented. No substance-specific human data are available.
No validated human data exist for this substance. The risk profile is extrapolated from class characteristics. Structural-chemical features may hint at possible mechanisms but do not substitute for substance-specific preclinical or clinical data.
Class-based — no substance-specific primary literature
Where does this assessment come from?
Known — structure-based
Derived from stimulant class profile and structural-chemical features.
Suspected — class-based
Extrapolated from known stimulant profile: catecholamine release, cardiovascular strain.
Unknown — no human data
Substance-specific data on pharmacokinetics, dose range and long-term effects are entirely absent.
Deep-dive intelligence
Community reports and forum discussions exist for this substance. Synapedia treats these as monitoring signals, not verified human data. Reports may be confounded by tolerance, polydrug use and unverified product identities.
Community reports are uncontrolled. It often remains unclear:
Synapedia documents community signals but does not derive dose ranges or equivalences from them.
Receptor Targets
Mechanism of Action
3-CMC acts through the following pharmacological mechanisms:
Designations
Receptor Profile
Der Serotonintransporter (SERT/5-HTT) ist ein Natrium-abhängiger Monoamintransporter, der Serotonin aus dem synaptischen Spalt zurück in die präsynaptische Zelle transportiert. Er ist das primäre Ziel von SSRI und MDMA.
Der Noradrenalintransporter (NET) ist ein Monoamintransporter, der Noradrenalin aus dem synaptischen Spalt zurücktransportiert. Er wird von verschiedenen Stimulants und Antidepressiva beeinflusst.
Der Dopamintransporter (DAT) ist ein Natrium-abhängiger Monoamintransporter, der Dopamin aus dem synaptischen Spalt entfernt. Er ist ein zentrales Ziel von Stimulants und spielt eine Schlüsselrolle im Belohnungssystem.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class.
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Dosage & Duration translation in progress
English prose is being expanded. The German version currently has more detail.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks & Harm Reduction translation in progress
English prose is being expanded. Safety-critical structured data may still be shown when available.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interactions translation in progress
English prose is being expanded. Safety-critical structured data may still be shown when available.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
Effects that 3-CMC shares with related substances.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
Share a report, observation, or question about this substance. Entries are reviewed before publication and marked as unverified community signals.
These entries are submitted by users and are not verified. They may contain subjective experiences, observations, source leads, or corrections. They do not replace scientific data and are not consumption advice.
The signal hub collects approved risk signals, experience reports and source leads by relevance.