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4-amino-3-(4-chlorophenyl)butanoic acid
Baclofen is a centrally acting muscle relaxant that acts as a selective GABA-B receptor agonist. It is primarily used for the treatment of muscle spasticity and also shows potential in supporting addiction disorders. The substance affects neuronal excitability by inhibiting neurotransmitter release. Side effects may include sedation and muscle weakness.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Designations
IUPAC: Baclofen
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der GABA-B-Rezeptor ist ein Gi/Go-gekoppelter metabotroper GABA-Rezeptor, der als Heterodimer (GABA-B1/B2) funktioniert. Er moduliert die Neurotransmitterfreisetzung und vermittelt langsame inhibitorische postsynaptische Potenziale.
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration 6-8 hours
Peak
2-4 hours
Onset
1-2 hours
Total duration
6-8 hours
After effects
Unclear
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Summary
Mögliche Nebenwirkungen umfassen Schläfrigkeit, Schwindel und Übelkeit.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some combinations can be dangerous. Research before combining substances.
Synergistische GABAerge Depression
Baclofen ist ein selektiver GABA-B-Agonist. Obwohl Baclofen klinisch auch zur Behandlung von Alkoholabhängigkeit eingesetzt wird, kann die Kombination in unkontrollierten Settings zu schwerer Sedierung, Atemdepression und Bewusstlosigkeit führen. Die unterschiedlichen GABAergen Angriffspunkte (GABA-A vs. GABA-B) führen zu einer breiten GABAergen Überaktivierung.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.