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GHB is an endogenous neurotransmitter derivative and primarily acts as a sedative and anesthetic by activating GHB and GABAB receptors. It is medically used, among other things, for the treatment of narcolepsy, but carries a high risk of dependence and overdose. The effects include relaxation, euphoria, and at higher doses, disturbances of consciousness. Due to its narrow therapeutic window and the risk of respiratory depression, caution is advised.
Class
Depressiva
Pharmacological context
Mechanism
GHB ist ein endogenes GABA-Metabolit und Neuromodulator. Es wirkt...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: GHB
Synapedia Evidence
Frequently checked combinations
Effects & Pharmacology is partially translated. Some details are still being expanded.
GHB ist ein endogenes GABA-Metabolit und Neuromodulator. Es wirkt primär als Agonist an spezifischen GHB-Rezeptoren (hochaffine neuromodulatorsiche Wirkung bei physiologischen Konzentrationen). Bei Freizeitdosen wirkt GHB als vollständiger Agonist am GABA-B-Rezeptor (Gi-Protein-gekoppelt: K+-Kanal-Aktivierung, Ca²+-Kanal-Inhibition). Dies erklärt die sedierenden, euphorischen und amnesestischen Effekte. Bei sehr hohen Dosen zeigt sich positive allosterische Modulation am GABA-A-Rezeptor. Das extrem enge therapeutische Fenster (1g Unterschied zwischen Sedation und Bewusstlosigkeit) macht GHB besonders gefährlich.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 2–4 g
Total duration 3–4 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 1–2 g |
| Reported | 2–4 g |
| Strong | 4–6 g |
Rektal
| Tier | Dosage |
|---|---|
| Light | 1–2 g |
| Reported | 2–4 g |
| Strong | 4–6 g |
Onset
15–30 minutes
Peak
1–2 hours
Total duration
3–4 hours
After effects
1–3 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Evidence
strong
Safer Use
Depressant-risk context
This substance belongs to a context where combinations with opioids, benzodiazepines, alcohol, GHB/GBL, or other sedating substances can increase sedation, blackout, aspiration, and breathing-risk patterns. Risk Check can review warning patterns; it is not medical advice and it cannot clear a combination as safe.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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