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8-chloro-1-methyl-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
Alprazolam is a benzodiazepine primarily used for the treatment of anxiety disorders and panic disorders. It acts by enhancing GABA-mediated inhibition in the central nervous system, leading to calming, anxiolytic, and muscle-relaxing effects. Due to its potential for dependence and withdrawal symptoms, cautious use is recommended.
Receptor Targets
Mechanism of Action
Designations
IUPAC: Alprazolam
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der GABA-A-Rezeptor ist ein ligandengesteuerter Chloridkanal und der wichtigste inhibitorische Rezeptor im zentralen Nervensystem. Er besitzt multiple allosterische Bindungsstellen für verschiedene Substanzklassen.
Alprazolam acts as an agonist at the GABA-A receptor, which enhances the inhibitory effect of GABA in the central nervous system. This leads to a reduction in anxiety and a calming of the nervous system.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 6-12 hours
Peak
1-2 hours
Onset
30-60 minutes
Total duration
6-12 hours
After effects
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Summary
Alprazolam kann zu Abhängigkeit führen und hat ein Risiko für Missbrauch.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some combinations can be dangerous. Research before combining substances.
Lebensbedrohlich: Extreme ZNS-Depression durch kurzwirksames Benzodiazepin und Alkohol
Alprazolam ist ein hochpotentes, kurzwirksames Benzodiazepin, das als positiver allosterischer Modulator am GABA-A-Rezeptor wirkt. Ethanol verstärkt ebenfalls die GABAerge Neurotransmission und wirkt zusätzlich als NMDA-Antagonist. Die Kombination führt zu einer überadditiven Verstärkung der ZNS-Depression mit erhöhtem Risiko für Bewusstlosigkeit, Atemdepression und Tod. Die schnelle Anflutung von Alprazolam macht diese Kombination besonders unberechenbar.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.