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Phenibut is a substance from the class of phenethylamines. Further information will follow after enrichment.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Designations
IUPAC: 4-amino-3-phenyl-butyric acid
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration 6-12 hours
Peak
2-4 hours
Onset
1-2 hours
Total duration
6-12 hours
After effects
2-6 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some combinations can be dangerous. Research before combining substances.
Lebensbedrohlich: Doppelte GABA-B-Aktivierung mit enger therapeutischer Breite
Beide Substanzen sind GABA-B-Agonisten. Die doppelte Aktivierung desselben Rezeptorsystems führt zu einer synergistischen ZNS-Depression. GHB hat zusätzlich eine steile Dosis-Wirkungs-Kurve, was die Kombination besonders gefährlich macht.
Schwere ZNS-Depression: Doppelte GABAerge Verstärkung
Phenibut aktiviert GABA-B-Rezeptoren und bindet an α2δ-Calciumkanal-Untereinheiten. Ethanol potenziert GABA-A-Rezeptoren. Die Kombination führt zu einer ausgeprägten GABAergen Überaktivierung mit Risiko für schwere Sedierung, Atemdepression und Bewusstlosigkeit.
Additive Atemdepression: GABA-B + Opioid-System
Phenibut verstärkt die GABAerge Inhibition über GABA-B-Rezeptoren. In Kombination mit Opioiden entsteht eine additive Hemmung des Atemzentrums. Die verzögerte Wirkung von Phenibut kann zu einer Fehleinschätzung des Wirkungszeitpunkts führen.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.