Laden…
methyl (1R,2R,3S,5S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
Cocaine is a powerful stimulant that primarily acts by inhibiting the reuptake of dopamine, norepinephrine, and serotonin. It leads to increased alertness, euphoria, and heightened physical activity, but carries a high risk of addiction and cardiovascular complications. Cocaine is also used as a local anesthetic, but has a high potential for abuse and can cause serious health damage.
Class
Stimulants
Pharmacological context
Mechanism
Cocaine acts as an inhibitor of the dopamine transporter (DAT) and...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
High Risk
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: (1R,2R,3S,5S)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Frequently checked combinations
Cocaine acts as an inhibitor of the dopamine transporter (DAT) and increases the availability of dopamine in the synaptic cleft. This leads to enhanced dopaminergic activity, which is responsible for the stimulating effects.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 50–100 mg
Total duration 1–2 hours
Nasal
| Tier | Dosage |
|---|---|
| Light | 20–50 mg |
| Reported | 50–100 mg |
| Strong | 100–200 mg |
Geraucht
| Tier | Dosage |
|---|---|
| Light | 50–100 mg |
| Reported | 100–200 mg |
| Strong | 200–300 mg |
IV
| Tier | Dosage |
|---|---|
| Light | 10–30 mg |
| Reported | 30–60 mg |
| Strong | 60–100 mg |
Onset
1–5 minutes (intravenous/smoked), 15–30 minutes (nasal)
Peak
30–60 minutes
Total duration
1–2 hours
After effects
1–2 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Overdose Risk
Kardiotoxizität ist die häufigste Todesursache. Herzrhythmusstörungen, Myokardinfarkt und zerebrale Ereignisse können gleichzeitig auftreten. Naloxon ist wirkungslos. Natriumbicarbonat kann bei Na⁺-Kanal-vermittelten Arrhythmien eingesetzt werden.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
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Based on substance class, receptors, mechanisms, and effect profile.
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