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2-[1-(aminomethyl)cyclohexyl]acetic acid
Gabapentin is an anticonvulsant and sedative primarily used for the treatment of neuropathic pain and epilepsy. It works by binding to the α2δ subunit of voltage-gated calcium channels, thereby modulating the release of excitatory neurotransmitters. The substance has a moderate risk profile, particularly when taken concurrently with other central depressants. Gabapentin is also used off-label for various indications.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Designations
IUPAC: 2-[1-(aminomethyl)cyclohexyl]acetic acid
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration 8-12 hours
Peak
2-3 hours
Onset
1-2 hours
Total duration
8-12 hours
After effects
Variable
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some combinations can be dangerous. Research before combining substances.
Erhöhte Atemdepression bei Opioid-Komedikation
Gabapentin reduziert die exzitatorische Neurotransmission über α2δ-Calciumkanal-Bindung. In Kombination mit Opioiden steigt das Risiko für Atemdepression. Die FDA hat 2019 eine Warnung zur Kombination von Gabapentinoiden und Opioiden herausgegeben.
Verstärkte ZNS-Depression und kognitive Beeinträchtigung
Gabapentin und Ethanol wirken beide ZNS-depressiv, wenn auch über unterschiedliche Mechanismen. Die Kombination verstärkt Sedierung, Schwindel und kognitive Beeinträchtigung. In hohen Dosen kann additive Atemdepression auftreten.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.