Laden…
Ayahuasca is a traditional psychedelic brew from South America that primarily combines DMT-containing plants with MAO inhibitors. It acts primarily as a 5-HT2A receptor agonist and allows for the oral activity of DMT through MAO inhibition. The substance is used in ritual and therapeutic contexts and can evoke intense visual and emotional experiences. Risks are particularly present when taken concurrently with serotonergic medications or in the case of pre-existing mental health conditions.
Class
Tryptamine
Pharmacological context
Mechanism
Ayahuasca wirkt hauptsächlich durch die Aktivierung von...
Short read on known pharmacology
Interactions
4 documented
Curated visible combinations
Risk theme
4 high-risk interactions
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Mechanism of Action
Designations
IUPAC: Ayahuasca
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Reported range 100–200 ml
Total duration 4–8 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 50–100 ml |
| Reported | 100–200 ml |
| Strong | 200–400 ml |
Oral
Onset
30–60 minutes
Peak
1–2 hours
Total duration
4–8 hours
After effects
1–3 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche psychische und physische Risiken, insbesondere bei Vorerkrankungen.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some entries are pharmacological class warnings. They are useful safety signals, but not substance-specific clinical validation.
Some combinations can be dangerous. Research before combining substances. For breathing problems, unconsciousness, seizures, chest pain, high fever, or severe confusion, contact emergency services.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
Share a report, observation, or question about this substance. Entries are reviewed before publication and marked as unverified community signals.
These entries are submitted by users and are not verified. They may contain subjective experiences, observations, source leads, or corrections. They do not replace scientific data and are not consumption advice.
The signal hub collects approved risk signals, experience reports and source leads by relevance.