Laden…
1-(1,3-benzodioxol-5-yl)-N-methylpropan-2-amine
MDMA, also known as Ecstasy, is a psychoactive substance commonly used in party cultures. It has both stimulating and empathogenic properties that can enhance emotional experiences and social interactions.
Class
Empathogens
Pharmacological context
Mechanism
MDMA is a non-selective monoamine releaser and reuptake inhibitor. Its...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: MDMA
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Frequently checked combinations
Effects & Pharmacology is partially translated. Some details are still being expanded.
MDMA is a non-selective monoamine releaser and reuptake inhibitor. Its primary mechanism involves TAAR1 activation, which triggers PKA/PKC-mediated phosphorylation of monoamine transporters (SERT >> NET > DAT) and reverses transporter flow, causing substantial serotonin, norepinephrine and dopamine release into the synaptic cleft. MDMA is a substrate for SERT, NET and DAT (carrier mechanism), not a pure reuptake inhibitor. It also inhibits VMAT2-mediated vesicular storage and directly depletes monoamine stores. 5-HT2A agonism contributes to entactogenic and empathogenic effects.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 75–125 mg
Total duration 4–6 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 50–75 mg |
| Reported | 75–125 mg |
| Strong | 125–200 mg |
Oral
Onset
30–60 minutes
Peak
1–2 hours
Total duration
4–6 hours
After effects
1–2 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Evidence
strong
Neurotoxicity
possible
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Aggregated signals from 12 experience reports on MDMA.
From 7 of 12 reports
Community data from 12 reports. Not a scientific assessment.
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Based on substance class, receptors, mechanisms, and effect profile.
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