Laden…
Methamphetamine is a powerful central nervous system stimulant that can produce a high level of dependence. It is often used abusively and has serious health consequences.
Class
Stimulants
Pharmacological context
Mechanism
Methamphetamine acts by inhibiting the reuptake of dopamine,...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
High Risk
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: Methamphetamin
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Methamphetamine acts by inhibiting the reuptake of dopamine, norepinephrine, and serotonin and increasing their release from presynaptic neurons. This leads to enhanced stimulation of the central nervous system.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 10–30 mg
Total duration 8–24 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 5–10 mg |
| Reported | 10–30 mg |
| Strong | 30–100 mg |
Nasal
| Tier | Dosage |
|---|---|
| Light | 5–10 mg |
| Reported | 10–30 mg |
| Strong | 30–100 mg |
Geraucht
| Tier | Dosage |
|---|---|
| Light | 5–10 mg |
| Reported | 10–30 mg |
| Strong | 30–100 mg |
IV
| Tier | Dosage |
|---|---|
| Light | 5–10 mg |
| Reported | 10–30 mg |
| Strong | 30–100 mg |
Onset
5–30 minutes
Peak
1–3 hours
Total duration
8–24 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Evidence
strong
Neurotoxicity
likely
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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