Laden…
(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Morphine is a potent opioid analgesic that primarily acts through the activation of μ-opioid receptors. It is used for the treatment of severe pain but carries a high risk of dependence and side effects such as respiratory depression. Morphine is a naturally occurring alkaloid derived from the opium poppy and plays a central role in pain therapy.
Class
Opioide
Pharmacological context
Mechanism
Morphine primarily acts as an agonist at the μ-opioid receptor, leading...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
High Risk
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: (4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Synapedia Evidence
Morphine primarily acts as an agonist at the μ-opioid receptor, leading to the inhibition of pain transmission in the central nervous system. This results in analgesic and sedative effects.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 10–30 mg
Total duration 4–6 hours (oral), 3–4 hours (intravenous)
Oral
| Tier | Dosage |
|---|---|
| Light | 5–10 mg |
| Reported | 10–30 mg |
| Strong | 30–100 mg |
IV
| Tier | Dosage |
|---|---|
| Light | 1–5 mg |
| Reported | 5–10 mg |
| Strong | 10–30 mg |
Onset
30–60 minutes (oral), 5–10 minutes (intravenous)
Peak
60–90 minutes (oral), 15–30 minutes (intravenous)
Total duration
4–6 hours (oral), 3–4 hours (intravenous)
After effects
2–4 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks & Harm Reduction is partially translated. Some details are still being expanded.
Risks
Overdose Risk
Klassische Opioidüberdosierungs-Trias: Atemdepression + Koma + Miosis. Naloxon (Opioidantagonist) ist das spezifische Antidot. Wichtig: Naloxons Halbwertzeit (30–90 min) ist kürzer als die von Morphin (2–4h) — Re-Sedierung nach Naloxon-Gabe ist möglich. Notruf 112 ist immer erforderlich.
Safer Use
Depressant-risk context
This substance belongs to a context where combinations with opioids, benzodiazepines, alcohol, GHB/GBL, or other sedating substances can increase sedation, blackout, aspiration, and breathing-risk patterns. Risk Check can review warning patterns; it is not medical advice and it cannot clear a combination as safe.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
Share a report, observation, or question about this substance. Entries are reviewed before publication and marked as unverified community signals.
These entries are submitted by users and are not verified. They may contain subjective experiences, observations, source leads, or corrections. They do not replace scientific data and are not consumption advice.
The signal hub collects approved risk signals, experience reports and source leads by relevance.