Laden…
7-chloro-1-methyl-5-phenyl-3H-1,4-benzodiazepin-2-one
Diazepam is a benzodiazepine that primarily acts by enhancing GABA-A receptor activity. It is medically used for the treatment of anxiety disorders, muscle spasms, and epileptic seizures. Due to its potential for dependence and withdrawal syndrome, cautious handling is required. Diazepam possesses sedative, anxiolytic, and anticonvulsant properties.
Class
Depressiva
Pharmacological context
Mechanism
Diazepam acts as an agonist at the GABA-A receptor, leading to...
Short read on known pharmacology
Interactions
3 documented
Curated visible combinations
Risk theme
3 high-risk interactions
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: Diazepam
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Diazepam acts as an agonist at the GABA-A receptor, leading to increased inhibition of neuronal activity. This results in anxiolytic, sedative, and muscle relaxant effects.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 5–10 mg
Total duration 6–8 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 2–5 mg |
| Reported | 5–10 mg |
| Strong | 10–20 mg |
Oral
Onset
30–60 minutes
Peak
1–2 hours
Total duration
6–8 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Overdose Risk
Diazepam allein ist bei Erwachsenen selten direkt tödlich. Die Kombinationstoxizität mit Opioiden, Alkohol oder anderen Sedativa ist verantwortlich für die meisten Todesfälle. Antidot: Flumazenil (Benzodiazepinantagonist) — kurzwirkend (0,5–2h), Resedierung ist möglich. Verlängerte Überwachung nach Flumazenil-Antidotierung notwendig.
Safer Use
Depressant-risk context
This substance belongs to a context where combinations with opioids, benzodiazepines, alcohol, GHB/GBL, or other sedating substances can increase sedation, blackout, aspiration, and breathing-risk patterns. Risk Check can review warning patterns; it is not medical advice and it cannot clear a combination as safe.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some combinations can be dangerous. Research before combining substances. For breathing problems, unconsciousness, seizures, chest pain, high fever, or severe confusion, contact emergency services.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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