Laden…
Synapedia is an independent knowledge project about psychoactive substances and harm reduction. If the platform helps you learn something new, you can support its development.
Every bit helps keep the project alive.
Etizolam is a thienodiazepine-like sedative with anxiolytic, hypnotic, and muscle-relaxant properties. It primarily acts as an agonist at the GABA-A receptor, leading to enhanced inhibitory neurotransmission in the central nervous system. Due to its pharmacological effects, it is therapeutically used for the treatment of anxiety disorders and sleep disturbances. The risk of dependence and withdrawal symptoms is moderate and should be considered with prolonged use.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Designations
IUPAC: Etizolam
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der GABA-A-Rezeptor ist ein ligandengesteuerter Chloridkanal und der wichtigste inhibitorische Rezeptor im zentralen Nervensystem. Er besitzt multiple allosterische Bindungsstellen für verschiedene Substanzklassen.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class. Limited data — interpret profile with caution.
Effects & Pharmacology is partially translated. Some content may appear in German.
Etizolam acts as an agonist at the GABA-A receptor, resulting in enhanced inhibition of neuronal activity. This leads to anxiolytic, sedative, and muscle-relaxant effects.
Total duration 6-8 hours
Peak
1-2 hours
Onset
30-60 minutes
Total duration
6-8 hours
After effects
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, and pre-existing conditions significantly affect outcomes.
Risks
Summary
Mögliche Abhängigkeit und Toleranzentwicklung bei längerem Gebrauch.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some combinations can be dangerous. Research before combining substances.
Atemdepression: Thienodiazepin + Opioid
Etizolam ist ein Thienodiazepin mit benzodiazepinähnlicher Pharmakologie am GABA-A-Rezeptor. Die Kombination mit Opioiden folgt dem bekannten Benzodiazepin-Opioid-Atemdepressionsrisiko. Etizolam wird als Research Chemical vertrieben und ist in vielen Ländern nicht reguliert, was zu unkalkulierbarer Dosierung beiträgt.
ZNS-Depression: Thienodiazepin + Alkohol
Etizolam und Ethanol potenzieren beide die GABAerge Neurotransmission am GABA-A-Rezeptor. Die Wechselwirkung entspricht der zwischen Benzodiazepinen und Alkohol: verstärkte Sedierung, Ataxie, Amnesie und Atemdepressionsrisiko.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.